1. TRPC1, TRPC3, and TRPC6 channels are all involved in cardiac hypertrophy . 2. The newer Harvard study claimed GDF11 does in fact reverse age-related cardiac hypertrophy . 3. More recently, Endonuclease G is considered a determinant of cardiac hypertrophy . 4. However, S100A1-/-did not show the eventual cardiac hypertrophy or chamber dilation in aged mice. 5. ATGL deficient mice administered pirinixic acid demonstrated reduced cardiac hypertrophy and improved cardiac function. 6. Decreasing intramitochondrial allows for reversal of cardiac hypertrophy caused in the original cardiac response. 7. CsA has been shown to decrease cardiac hypertrophy by affecting cardiac myocytes in many ways. 8. A study of congenital heart defect ( CHD ) investigated the septal defects and cardiac hypertrophy . 9. Ciclosporin has been used experimentally to treat cardiac hypertrophy ( an increase in cell volume ). 10. These data suggest that upregulation of talin-1 in cardiac hypertrophy may be detrimental to cardiomyocytes function.
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